By Erkki Nissinen
- Up-to-date precis of biochemistry and pharmacology of COMT and its inhibitors
- Preclinical versions in COMT inhibitor devlopment
- Transgenic COMT mice – most up-to-date details summarized
- Chemistry of COMT inhibitors and their layout with molecular modelling
- COMT gene and its law and relation to dopamine comparable diseases
- Role of cofactor SAM law with regards to homocysteine
- Nonclinical and scientific safeguard of COMT inhibitors summarized
- Future clients of COMT inhibitors in Parkinson’s disease
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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors: 95 (International Review of Neurobiology) by Erkki Nissinen